Mix E, Meyer-Rienecker H, Zettl U K
Klinik und Poliklinik für Neurologie, Universität Rostock, Gehlsheimer Strasse 20, Rostock.
Fortschr Neurol Psychiatr. 2009 Aug;77 Suppl 1:S14-20. doi: 10.1055/s-0028-1109612. Epub 2009 Aug 14.
Animal models play an important role for exploration of the aetiology, pathogenesis and therapy of various neurological diseases. Their benefit and limitations are being discussed mainly focussed at experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). To answer specific questions concerning the genetics, pathogenesis, diagnostics and treatment of inflammatory, degenerative, ischemic, traumatic und neoplastic diseases of the nervous system different animal models are needed. So far, these are only partially available. Rarely there are alternative methods such as cell, tissue and organ cultures and computer simulations. New phase-specific biomarkers are needed in order to improve the potency of experimental results to be translated into clinical practice.
动物模型在探索各种神经疾病的病因、发病机制和治疗方法方面发挥着重要作用。人们主要围绕实验性自身免疫性脑脊髓炎（EAE）这一多发性硬化症（MS）的动物模型，讨论了它们的益处和局限性。为了回答有关神经系统炎症性、退行性、缺血性、创伤性和肿瘤性疾病的遗传学、发病机制、诊断和治疗的具体问题，需要不同的动物模型。到目前为止，这些模型只是部分可用。很少有细胞、组织和器官培养以及计算机模拟等替代方法。为了提高将实验结果转化为临床实践的效力，需要新的阶段特异性生物标志物。
