Wolters A
Klinik und Poliklinik für Neurologie, Universität Rostock, Gehlsheimer Strasse 20, Rostock.
Fortschr Neurol Psychiatr. 2009 Aug;77 Suppl 1:S61-3. doi: 10.1055/s-0028-1109608. Epub 2009 Aug 14.
In patients with primary generalized or segmental dystonia controlled studies have shown that bilateral pallidal deep brain stimulation (DBS) can reduce disability scores by 40 to 60 %. Up to now, the data base on the therapeutic effects of DBS in selected patients with focal dystonia is less extensive. Long-term efficacy of DBS in dystonia has been demonstrated, but reports have focused mainly on patients with primary generalized dystonia so far, with a mean observation period of approximately 5 years. Predictors of a favourable long-term efficacy of DBS in primary generalized dystonia patients are young age at surgery, a shorter duration of the disease, a lower severity of disability, and a posteroventrolateral localization of the DBS electrode within the globus pallidus internus (GPi). Controlled studies are needed to identify also the factors determining the best long-term outcome of non-generalized dystonia patients treated with DBS.
在原发性全身性或节段性肌张力障碍患者中，对照研究表明，双侧苍白球深部脑刺激（DBS）可使残疾评分降低40%至60%。到目前为止，关于DBS对部分局灶性肌张力障碍患者治疗效果的数据库尚不广泛。DBS治疗肌张力障碍的长期疗效已得到证实，但迄今为止，报告主要集中在原发性全身性肌张力障碍患者，平均观察期约为5年。DBS对原发性全身性肌张力障碍患者长期疗效良好的预测因素包括手术时年龄较轻、病程较短、残疾程度较低以及DBS电极在苍白球内侧核（GPi）内的后腹外侧定位。还需要进行对照研究，以确定决定接受DBS治疗的非全身性肌张力障碍患者最佳长期疗效的因素。
