Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
Macromol Biosci. 2009 Nov 10;9(11):1116-26. doi: 10.1002/mabi.200900135.
An amino-acid-based hydrophobically modified biocompatible copolymer, poly[(sodium N-acryloyl-L-valinate)-co-(N-octylacrylamide)] was synthesized and characterized. Techniques such as fluorescence probes, DLS, and TEM were used to investigate its aggregation behavior in aqueous solution. The copolymer was observed to form micellar aggregates having diameters in the nanometer range in aqueous solution (pH = 8) through inter-chain hydrophobic association. This behavior was found to be similar to that of poly[(sodium N-acryloyl-L-valinate)-co-(N-dodecylacrylamide)]. The compact micellar nanostructures were observed to be stable with respect to changes of pH and temperature. The encapsulation and release of griseofulvin, a hydrophobic model drug, was studied.
一种基于氨基酸的疏水改性生物相容性共聚物，聚[（N-丙烯酰基-L-缬氨酸）-共-（N-辛基丙烯酰胺）]被合成并进行了表征。荧光探针、DLS 和 TEM 等技术被用于研究其在水溶液中的聚集行为。共聚物通过链间疏水缔合被观察到在水溶液（pH=8）中形成具有纳米级直径的胶束聚集。这种行为与聚[（N-丙烯酰基-L-缬氨酸）-共-（N-十二烷基丙烯酰胺）]相似。观察到紧凑的胶束纳米结构在 pH 和温度变化时稳定。疏水性模型药物灰黄霉素的包封和释放进行了研究。
