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Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours.

作者信息

Granchi Carlotta, Funaioli Tiziana, Erler Janine T, Giaccia Amato J, Macchia Marco, Minutolo Filippo

机构信息

Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, I-56126 Pisa (Italy).

出版信息

ChemMedChem. 2009 Oct;4(10):1590-4. doi: 10.1002/cmdc.200900247.

DOI:10.1002/cmdc.200900247
PMID:19685543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3050608/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/0299969733f6/nihms195167f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/68adecbfcde3/nihms195167f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/f58b00ba8c94/nihms195167f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/e14353d59d79/nihms195167f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/366c65b86847/nihms195167f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/0299969733f6/nihms195167f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/68adecbfcde3/nihms195167f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/f58b00ba8c94/nihms195167f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/e14353d59d79/nihms195167f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/366c65b86847/nihms195167f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed5e/3050608/0299969733f6/nihms195167f5.jpg

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本文引用的文献

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PLoS One. 2009;4(5):e5620. doi: 10.1371/journal.pone.0005620. Epub 2009 May 19.
2
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.缺氧诱导的赖氨酰氧化酶是骨髓细胞募集以形成前转移微环境的关键介质。
Cancer Cell. 2009 Jan 6;15(1):35-44. doi: 10.1016/j.ccr.2008.11.012.
3
Design of anticancer prodrugs for reductive activation.
赖氨酸氧化酶工程化脂质纳米囊泡用于治疗三阴性乳腺癌。
Sci Rep. 2021 Mar 3;11(1):5107. doi: 10.1038/s41598-021-84492-3.
4
Hypoxia-targeted drug delivery.缺氧靶向药物递送。
Chem Soc Rev. 2019 Feb 4;48(3):771-813. doi: 10.1039/c8cs00304a.
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Evaluation of Fluorine-18-Labeled α1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase.评估氟-18标记的α1(I)-N-端肽类似物作为基于底物的放射性示踪剂用于黑色素瘤相关赖氨酰氧化酶的PET成像。
Front Chem. 2018 Apr 26;6:121. doi: 10.3389/fchem.2018.00121. eCollection 2018.
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