Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours.
作者信息
Granchi Carlotta, Funaioli Tiziana, Erler Janine T, Giaccia Amato J, Macchia Marco, Minutolo Filippo
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, I-56126 Pisa (Italy).
出版信息
ChemMedChem. 2009 Oct;4(10):1590-4. doi: 10.1002/cmdc.200900247.
Abstract
摘要
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本文引用的文献
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The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells.赖氨酰氧化酶抑制剂β-氨基丙腈可降低循环乳腺癌细胞的转移定植潜能。
PLoS One. 2009;4(5):e5620. doi: 10.1371/journal.pone.0005620. Epub 2009 May 19.
2
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.缺氧诱导的赖氨酰氧化酶是骨髓细胞募集以形成前转移微环境的关键介质。
Cancer Cell. 2009 Jan 6;15(1):35-44. doi: 10.1016/j.ccr.2008.11.012.
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Design of anticancer prodrugs for reductive activation.用于还原激活的抗癌前药设计。
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