Zhu Qiubei, Zhang Suqin, Wu Jingxian, Tang Haihong
Department of Otolaryngology Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Apr;23(8):339-42.
To investigate the expression of neuropeptides in the nasal septum of the perennial allergic rhinitis patients, and the mechanism of the alleviation effect of nasal septum rectification to allergic rhinitis.
Forty-five patients with deviation of nasal septum (20 with allergic rhinitis and 25 without), who undergone nasal septum rectification in Changhai hospital during Jun to Dec, 2007, were included in this research. The levels of SP, VIP, CGRP of the nasal septum were determined by radioimmunoassay.
In the normal controls, the SP, VIP and CGRP levels of the nasal septal cartilages were lower than that of the nasal septal bones (P<0.05), while in the perennial allergic rhinitis patients group, there were no statistical significance between the SP, VIP levels of the nasal septal cartilages and that of the nasal septal bones (P>0.05), and the CGRP level of the nasal septal cartilages was higher than that of the nasal septal bones (P<0.05). The SP, VIP levels of the nasal septal cartilages in the perennial allergic rhinitis patients group were higher than that in the normal controls (P<0.05), and there were no statistical significance between the levels of the nasal septal bones in the two groups (P>0.05). There were no statistical significance between the CGRP levels of the nasal septal cartilages in the two groups (P>0.05), neither did that of the nasal septal bones in the two groups (P>0.05).
The SP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. The VIP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. There were no statistical significance between the CGRP levels of the nasal septum in the perennial allergic rhinitis patients and the normal controls.
探讨常年性变应性鼻炎患者鼻中隔中神经肽的表达情况，以及鼻中隔矫正术对变应性鼻炎缓解作用的机制。
选取2007年6月至12月在长海医院行鼻中隔矫正术的鼻中隔偏曲患者45例（其中变应性鼻炎患者20例，非变应性鼻炎患者25例）纳入本研究。采用放射免疫分析法测定鼻中隔中P物质（SP）、血管活性肠肽（VIP）、降钙素基因相关肽（CGRP）的水平。
正常对照组中，鼻中隔软骨的SP、VIP和CGRP水平低于鼻中隔骨（P<0.05）；而在常年性变应性鼻炎患者组中，鼻中隔软骨与鼻中隔骨的SP、VIP水平比较差异无统计学意义（P>0.05），鼻中隔软骨的CGRP水平高于鼻中隔骨（P<0.05）。常年性变应性鼻炎患者组鼻中隔软骨的SP、VIP水平高于正常对照组（P<0.05），两组鼻中隔骨水平比较差异无统计学意义（P>0.05）。两组鼻中隔软骨的CGRP水平比较差异无统计学意义（P>0.05），两组鼻中隔骨的CGRP水平比较差异也无统计学意义（P>0.05）。
常年性变应性鼻炎患者鼻中隔的SP水平高于正常对照组，在鼻中隔软骨中更明显。常年性变应性鼻炎患者鼻中隔的VIP水平高于正常对照组，在鼻中隔软骨中更明显。常年性变应性鼻炎患者与正常对照组鼻中隔的CGRP水平比较差异无统计学意义。
