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嗅觉受体的起始

Onset of odorant receptors.

作者信息

Rodriguez-Gil Diego J, Treloar Helen B, Miller Alexandra, Two Aimee, Iwema Carrie, Greer Charles A

机构信息

Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520-8082, USA.

出版信息

Ann N Y Acad Sci. 2009 Jul;1170:18-20. doi: 10.1111/j.1749-6632.2009.04366.x.

DOI:10.1111/j.1749-6632.2009.04366.x
PMID:19686100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2729770/
Abstract

Odorant receptors are thought to be critical determinants of olfactory sensory neuron axon targeting and organization. Nonetheless, a systematic characterization of the onset of odorant receptor expression has not yet been done in the main olfactory epithelium. Here, we briefly review our current understanding regarding the onset of odorant receptor expression in the main olfactory epithelium and identify some of those questions which we believe must be of high priority for future study.

摘要

气味受体被认为是嗅觉感觉神经元轴突靶向和组织的关键决定因素。尽管如此,主嗅觉上皮中气味受体表达起始的系统特征尚未得到研究。在此,我们简要回顾一下目前对主嗅觉上皮中气味受体表达起始的理解,并指出一些我们认为未来研究必须优先解决的问题。

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Onset of odorant receptors.嗅觉受体的起始
Ann N Y Acad Sci. 2009 Jul;1170:18-20. doi: 10.1111/j.1749-6632.2009.04366.x.
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Grouping of odorant receptors: odour maps in the mammalian olfactory bulb.气味受体的分组:哺乳动物嗅球中的气味图谱。
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[Expression of odorant receptor genes on the olfactory epithelium following olfactory nerve disconnection].[嗅神经离断后嗅上皮上气味受体基因的表达]
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Odorant receptor diversity and patterned gene expression in the mammalian olfactory epithelium.哺乳动物嗅觉上皮中的气味受体多样性与模式化基因表达。
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Role of a ubiquitously expressed receptor in the vertebrate olfactory system.广泛表达的受体在脊椎动物嗅觉系统中的作用。
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引用本文的文献

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Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation.Sema7A/PlxnCl 信号触发活性依赖的嗅觉突触形成。
Nat Commun. 2018 May 9;9(1):1842. doi: 10.1038/s41467-018-04239-z.
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Lhx2 Determines Odorant Receptor Expression Frequency in Mature Olfactory Sensory Neurons.Lhx2 决定成熟嗅觉感觉神经元中气味受体表达的频率。
eNeuro. 2016 Oct 31;3(5). doi: 10.1523/ENEURO.0230-16.2016. eCollection 2016 Sep-Oct.
3
Activity-dependent modulation of odorant receptor gene expression in the mouse olfactory epithelium.活性依赖的小鼠嗅上皮气味受体基因表达的调节。
PLoS One. 2013 Jul 29;8(7):e69862. doi: 10.1371/journal.pone.0069862. Print 2013.

本文引用的文献

1
Activity plays a role in eliminating olfactory sensory neurons expressing multiple odorant receptors in the mouse septal organ.活动在清除小鼠鼻中隔器官中表达多种气味受体的嗅觉感觉神经元方面发挥作用。
Mol Cell Neurosci. 2008 Aug;38(4):484-8. doi: 10.1016/j.mcn.2008.04.006. Epub 2008 Apr 23.
2
Differential development of odorant receptor expression patterns in the olfactory epithelium: a quantitative analysis in the mouse septal organ.嗅觉上皮中气味受体表达模式的差异发育:小鼠鼻中隔器官的定量分析
Dev Neurobiol. 2008 Mar;68(4):476-86. doi: 10.1002/dneu.20612.
3
Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice.腺苷酸环化酶3缺失扰乱小鼠外周嗅觉投射。
J Neurosci. 2007 Jun 20;27(25):6675-83. doi: 10.1523/JNEUROSCI.0699-07.2007.
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Adenylyl cyclase-dependent axonal targeting in the olfactory system.嗅觉系统中腺苷酸环化酶依赖性轴突靶向
Development. 2007 Jul;134(13):2481-9. doi: 10.1242/dev.006346. Epub 2007 May 30.
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A G protein/cAMP signal cascade is required for axonal convergence into olfactory glomeruli.轴突汇聚到嗅小球需要G蛋白/cAMP信号级联反应。
Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):1039-44. doi: 10.1073/pnas.0609215104. Epub 2007 Jan 10.
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Axonal wiring in the mouse olfactory system.小鼠嗅觉系统中的轴突布线。
Annu Rev Cell Dev Biol. 2006;22:713-37. doi: 10.1146/annurev.cellbio.21.012804.093915.
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Odorant receptor-derived cAMP signals direct axonal targeting.嗅觉受体衍生的环磷酸腺苷信号引导轴突靶向。
Science. 2006 Oct 27;314(5799):657-61. doi: 10.1126/science.1131794. Epub 2006 Sep 21.
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Noses and neurons: induction, morphogenesis, and neuronal differentiation in the peripheral olfactory pathway.鼻子与神经元:外周嗅觉通路中的诱导、形态发生及神经元分化
Dev Dyn. 2005 Nov;234(3):464-81. doi: 10.1002/dvdy.20582.
9
Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway.神经元钙传感器蛋白NCS-1在发育中小鼠嗅觉通路中的表达。
J Comp Neurol. 2005 Feb 7;482(2):201-16. doi: 10.1002/cne.20431.
10
Expression of olfactory receptors in the cribriform mesenchyme during prenatal development.产前发育期间筛状间充质中嗅觉受体的表达。
Gene Expr Patterns. 2004 Sep;4(5):543-52. doi: 10.1016/j.modgep.2004.02.004.