Friedrich Rainer W, Yaksi Emre, Judkewitz Benjamin, Wiechert Martin T
Friedrich Miescher Institute, Basel, Switzerland.
Ann N Y Acad Sci. 2009 Jul;1170:293-7. doi: 10.1111/j.1749-6632.2009.04010.x.
In order to analyze neuronal computations in the first olfactory processing center, the olfactory bulb, we measured odor-evoked activity patterns across large numbers of neurons within the intact olfactory bulb of zebrafish using optical and electrophysiological methods. We found that the olfactory bulb performs multiple computations including a decorrelation of overlapping inputs, a multiplexing of complementary information, and gain control. Patterns of olfactory bulb output activity are reorganized during the initial phase of an odor response, resulting in a partial loss of the topographic representation of molecular features and in the decorrelation of activity patterns evoked by similar stimuli. Physiological, pharmacological, and computational results provide initial insights into the mechanisms underlying these computations.
为了分析首个嗅觉处理中心——嗅球中的神经元计算，我们使用光学和电生理方法，测量了斑马鱼完整嗅球内大量神经元的气味诱发活动模式。我们发现，嗅球执行多种计算，包括重叠输入的去相关、互补信息的复用以及增益控制。在气味反应的初始阶段，嗅球输出活动模式会重新组织，导致分子特征的拓扑表征部分丧失，以及相似刺激诱发的活动模式去相关。生理学、药理学和计算结果为这些计算背后的机制提供了初步见解。
