Treeby Bradley E, Cox Benjamin T, Zhang Edward Z, Patch Sarah K, Beard Paul C
Department of Medical Physics and Bioengineering, University College London, London, UK.
IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Aug;56(8):1666-76. doi: 10.1109/TUFFC.2009.1231.
The broadband ultrasonic characterization of biological fluids and tissues is important for the continued development and application of high-resolution ultrasound imaging modalities. Here, a photoacoustic technique for the transmission measurement of temperature-dependent ultrasonic attenuation and dispersion is described. The system uses a photoacoustic plane wave source constructed from a polymethylmethacrylate substrate with a thin optically absorbent layer. Broadband ultrasonic waves are generated by illuminating the absorbent layer with nanosecond pulses of laser light. The transmitted ultrasound waves are detected by a planar 7-microm high-finesse Fabry-Perot interferometer. Temperature-induced thickness changes in the Fabry-Perot interferometer are tracked to monitor the sample temperature and maintain the sensor sensitivity. The measured -6 dB bandwidth for the combined source and sensor is 1 to 35 MHz, with an attenuation corrected signal level at 100 MHz of -10 dB. The system is demonstrated through temperature-dependent ultrasound measurements in castor oil and olive oil. Power law attenuation parameters are extracted by fitting the experimental attenuation data to a frequency power law while simultaneously fitting the dispersion data to the corresponding Kramers-Krönig relation. The extracted parameters are compared with other calibration measurements previously reported in the literature.
生物流体和组织的宽带超声特性对于高分辨率超声成像模式的持续发展和应用至关重要。在此,描述了一种用于测量与温度相关的超声衰减和频散的光声技术。该系统使用由带有薄光学吸收层的聚甲基丙烯酸甲酯基板构成的光声平面波源。通过用纳秒激光脉冲照射吸收层来产生宽带超声波。透射的超声波由平面7微米高精细度法布里-珀罗干涉仪检测。跟踪法布里-珀罗干涉仪中温度引起的厚度变化,以监测样品温度并保持传感器灵敏度。源和传感器组合的测量-6dB带宽为1至35MHz,在100MHz处的衰减校正信号电平为-10dB。通过在蓖麻油和橄榄油中进行与温度相关的超声测量来演示该系统。通过将实验衰减数据拟合到频率幂律,同时将频散数据拟合到相应的克拉默斯-克勒尼希关系,提取幂律衰减参数。将提取的参数与文献中先前报道的其他校准测量结果进行比较。