长效β2肾上腺素能受体激动剂福莫特罗对乙酰甲胆碱诱导的支气管收缩的作用。
Effect of formoterol, a long-lasting beta 2-adrenoceptor agonist, against methacholine-induced bronchoconstriction.
作者信息
Nix A, Nichol G M, Robson A, Barnes P J, Chung K F
机构信息
Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London.
出版信息
Br J Clin Pharmacol. 1990 Mar;29(3):321-4. doi: 10.1111/j.1365-2125.1990.tb03642.x.
Abstract
- The effects of a new long-acting inhaled beta 2-adrenoceptor agonist aerosol formoterol (12 micrograms), on FEV1, and on methacholine-induced bronchoconstriction, were compared with those of terbutaline (250 micrograms) and placebo in 12 midly asthmatic subjects. 2. PC20, the concentration of methacholine needed to cause a 20% fall in baseline FEV1, was determined 2 and 5 h after formoterol, terbutaline and placebo on separate days. Baseline PC20 was determined on a different day. 3. Compared with terbutaline and placebo, formoterol hastened recovery from methacholine-induced bronchoconstriction, and significantly increased mean PC20 (by 2.2- and 2.9-fold at 2 and 5 h respectively). 4. Thus, formoterol has a protective effect against methacholine-induced bronchoconstriction which lasts for at least 5 h.
摘要
- 在12名轻度哮喘患者中，将新型长效吸入型β2肾上腺素受体激动剂气雾剂福莫特罗（12微克）对第一秒用力呼气量（FEV1）以及对乙酰甲胆碱诱发的支气管收缩的作用，与特布他林（250微克）和安慰剂进行了比较。2. 分别在给予福莫特罗、特布他林和安慰剂后的第2小时和第5小时测定使基线FEV1下降20%所需的乙酰甲胆碱浓度（PC20）。基线PC20在不同日期测定。3. 与特布他林和安慰剂相比，福莫特罗能加速乙酰甲胆碱诱发的支气管收缩的恢复，并显著提高平均PC20（在2小时和5小时时分别提高2.2倍和2.9倍）。4. 因此，福莫特罗对乙酰甲胆碱诱发的支气管收缩具有保护作用，且该作用至少持续5小时。
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本文引用的文献
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Thorax. 1984 Jan;39(1):40-5. doi: 10.1136/thx.39.1.40.
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Dose related effects of salbutamol and ipratropium bromide on airway calibre and reactivity in subjects with asthma.沙丁胺醇和异丙托溴铵对哮喘患者气道口径及反应性的剂量相关效应。
Thorax. 1988 Apr;43(4):300-5. doi: 10.1136/thx.43.4.300.
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Bronchodilator drugs.支气管扩张剂药物
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