Hsiao Dun-Jen, Wu Lawrence Shih-Hsin, Huang Shih-Yi, Lin Eugene
College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
Pharmacogenet Genomics. 2009 Sep;19(9):730-3. doi: 10.1097/FPC.0b013e3283307cf1.
The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4+/-1.4 vs. 3.4+/-1.2 kg; P<0.001) and on body fat percentage loss (4.2+/-0.1 vs. 2.1+/-0.1%; P<0.001) in the combined TT+TC carriers. In contrast, sibutramine caused no significant additional effect on weight loss (P = 0.078) or on body fat percentage loss (P = 0.441) in homozygous C allele carriers.
西布曲明治疗后的体重减轻与鸟嘌呤核苷酸结合蛋白β多肽3（GNB3）基因中的单核苷酸多态性rs5443（C825T）之间的关系目前尚无定论。在本研究中，我们旨在重新评估GNB3 rs5443单核苷酸多态性是否会影响131名台湾肥胖患者在西布曲明治疗下的体重减轻和身体成分变化。通过协方差分析比较西布曲明组和安慰剂组，我们的数据显示，在TT + TC携带者组合中，西布曲明对体重减轻（7.4±1.4 vs. 3.4±1.2 kg；P<0.001）和体脂百分比降低（4.2±0.1 vs. 2.1±0.1%；P<0.001）有显著效果。相比之下，在纯合C等位基因携带者中，西布曲明对体重减轻（P = 0.078）或体脂百分比降低（P = 0.441）没有显著的额外影响。
