左金丸及其类方对大鼠胃寒模型影响的差异

Differences in effects of Zuojin Pills and its similar formulas on Wei cold model in rats.

作者信息

Zhao Yan-ling, Shi Wen-li, Shan Li-mei, Wang Jia-bo, Zhao Hai-ping, Xiao Xiao-he

机构信息

Institute of Traditional Chinese Material Medica, the 302 Hospital of PLA, Beijing, 100039, China.

出版信息

Chin J Integr Med. 2009 Aug;15(4):293-8. doi: 10.1007/s11655-009-0293-7. Epub 2009 Aug 18.

DOI:10.1007/s11655-009-0293-7

PMID:19688319

Abstract

OBJECTIVE

To explore the effects of Zuojin Pills and its similar formulas on the stomach cold syndrome in a Wei cold model in rats.

METHODS

The rat Wei cold model was established by intragastric administration of glacial NaOH, and the gastric mucosa injury indices, together with the levels of motilin and gastrin in the stomach, were determined. The preventive and curative effects of Zuojin Pills and its similar formulas on gastric mucosa injury were investigated.

RESULTS

Zuojin Pills and its similar formulas could protect the gastric mucosa in the gastric cold model in rats at different levels. Fanzuojin Pills had the best effect in inhibiting gastric mucosa injury.

CONCLUSION

The different pharmacological effects of Zuojin Pills and its similar formulas in the rat gastric cold model were partially correlated with the degrees in cold and heat properties of the formulas.

摘要