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在对患有严重肢体缺血的患者进行截肢前,务必联系血管介入专家。

Always contact a vascular interventional specialist before amputating a patient with critical limb ischemia.

机构信息

Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

出版信息

Cardiovasc Intervent Radiol. 2010 Jun;33(3):469-74. doi: 10.1007/s00270-009-9687-3. Epub 2009 Aug 18.

DOI:10.1007/s00270-009-9687-3
PMID:19688364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2868169/
Abstract

Patients with severe critical limb ischemia (CLI) due to long tibial artery occlusions are often poor candidates for surgical revascularization and frequently end up with a lower limb amputation. Subintimal angioplasty (SA) offers a minimally invasive alternative for limb salvage in this severely compromised patient population. The objective of this study was to evaluate the results of SA in patients with CLI caused by long tibial occlusions who have no surgical options for revascularization and are facing amputation. We retrospectively reviewed all consecutive patients with CLI due to long tibial occlusions who were scheduled for amputation because they had no surgical options for revascularization and who were treated by SA. A total of 26 procedures in 25 patients (14 males; mean age, 70 +/- 15 [SD] years) were evaluated. Technical success rate was 88% (23/26). There were four complications, which were treated conservatively. Finally, in 10 of 26 limbs, no amputation was needed. A major amputation was needed in 10 limbs (7 below-knee amputations and 3 above-knee amputations). Half of the major amputations took place within 3 months after the procedure. Cumulative freedom of major amputation after 12 months was 59% (SE = 11%). In six limbs, amputation was limited to a minor amputation. Seven patients (28%) died during follow-up. In conclusion, SA of the tibial arteries seem to be a valuable treatment option to prevent major amputation in patients with CLI who are facing amputation due to lack of surgical options.

摘要

患有因长段胫骨动脉闭塞引起的严重肢体缺血性疾病(CLI)的患者通常不适合进行手术血运重建,并且最终往往需要进行下肢截肢。内膜下血管成形术(SA)为严重肢体缺血患者提供了一种微创的保肢替代治疗方法。本研究的目的是评估 SA 在 CLI 患者中的应用效果,这些患者因长段胫骨动脉闭塞而无法进行手术血运重建,并且面临截肢风险。我们回顾性分析了所有因长段胫骨动脉闭塞导致 CLI 且无手术血运重建选择、计划进行截肢的连续患者的病例资料,这些患者接受了 SA 治疗。共评估了 25 例患者(14 例男性;平均年龄 70 +/- 15[SD]岁)的 26 例次 SA 治疗。技术成功率为 88%(23/26)。有 4 例并发症,均经保守治疗处理。最终,26 条肢体中有 10 条无需截肢。10 条肢体需要进行大截肢(7 例为膝下截肢,3 例为膝上截肢)。大截肢中有一半发生在手术 3 个月内。12 个月时主要截肢的无截肢生存率为 59%(SE=11%)。在 6 条肢体中,截肢限制为小截肢。7 例患者(28%)在随访期间死亡。结论:对于因缺乏手术选择而面临截肢的 CLI 患者,SA 治疗可作为预防大截肢的有效治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca55/2868169/71d515820696/270_2009_9687_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca55/2868169/d09be420c798/270_2009_9687_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca55/2868169/1b225e7edd41/270_2009_9687_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca55/2868169/71d515820696/270_2009_9687_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca55/2868169/d09be420c798/270_2009_9687_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca55/2868169/1b225e7edd41/270_2009_9687_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca55/2868169/71d515820696/270_2009_9687_Fig3_HTML.jpg

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本文引用的文献

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Cardiovasc Intervent Radiol. 2009 Jan;32(1):132-5. doi: 10.1007/s00270-008-9398-1. Epub 2008 Jul 26.
2
Infrapopliteal angioplasty for critical limb ischemia: relation of TransAtlantic InterSociety Consensus class to outcome in 176 limbs.下肢动脉成形术治疗严重肢体缺血:176例肢体的跨大西洋跨学会共识分类与预后的关系
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Subintimal angioplasty for peripheral arterial occlusive disease: a systematic review.
外周动脉闭塞性疾病的内膜下血管成形术:一项系统评价
Cardiovasc Intervent Radiol. 2008 Jul-Aug;31(4):687-97. doi: 10.1007/s00270-008-9331-7. Epub 2008 Apr 15.
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Progenitor cell therapy in patients with critical limb ischemia without surgical options.无手术选择的严重肢体缺血患者的祖细胞治疗
Ann Surg. 2008 Mar;247(3):411-20. doi: 10.1097/SLA.0b013e318153fdcb.
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The feasibility of a percutaneous temporary pedal bypass.经皮临时足部搭桥术的可行性。
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Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II).外周动脉疾病管理的跨学会共识(TASC II)
Eur J Vasc Endovasc Surg. 2007;33 Suppl 1:S1-75. doi: 10.1016/j.ejvs.2006.09.024. Epub 2006 Nov 29.
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Natural history of limbs with arterial insufficiency and chronic ulceration treated without revascularization.未经血管重建治疗的伴有动脉供血不足和慢性溃疡肢体的自然病史。
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