Nisoli E, Memo M, Missale C, Carruba M O, Spano P F
Institute of Pharmacology and Experimental Therapeutics, School of Medicine, University of Brescia, Italy.
Eur J Pharmacol. 1990 Jan 25;176(1):85-90. doi: 10.1016/0014-2999(90)90135-s.
Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 micrograms/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors.
研究了反复给予利苏瑞（一种选择性作用于D-2多巴胺（DA）受体的DA激动剂）后D-1和D-2多巴胺（DA）受体亚型的功能变化。通过测量用生理盐水或利苏瑞（100微克/千克腹腔注射）每日处理26天的大鼠不同脑区中SKF 82526刺激和溴隐亭抑制的腺苷酸环化酶活性，评估D-1和D-2 DA受体的功能状态。利苏瑞对纹状体、伏隔核、黑质、额叶皮质、海马体和垂体中的DA受体的持续刺激导致D-2受体下调，而不改变D-1受体的功能活性。
