Halloul Z, Weber M, Steinbach J, Bosselmann H-P, Pech M, Meyer F
University Hospital, Division of Vascular Surgery, Dept. of Surgery, Magdeburg, Germany.
Zentralbl Chir. 2009 Aug;134(4):316-21. doi: 10.1055/s-0029-1224530. Epub 2009 Aug 17.
Based on an extraordinary case -report on a patient with almost symptomless supramesenteric occlusion of the aorta, the successful management and favourable outcome including almost normalised renal function (in addition to appropriate diagnostic and operative tactics) achieved by a technically challenging vascular-surgical intervention and subsequent intensive medical and nephrological care are described.
In a 49-year-old male patient, a "high" aortic occlusion just below the branching of the coeliac trunk with arterial perfusion of the abdomen and the lower extremities via arterial collaterals from the 4 (th) to 6 (th) intercostal arteries was diagnosed. Both renal arteries were occluded leading to a consecutive renal insufficiency with need for dialysis and renovascularly induced hypertension. However, a residual perfusion of the parenchyma of the left kidney was detectable. Therapeutic measures comprised, after haemodialysis with accompanying antihypertensive medication, open supracoeliac aortobifemoral implantation of a prosthesis, revascularisation of the left renal artery (prosthetic bypass) and prostheticomesenteric bypass implantation. Postoperatively, a reestablished renal perfusion was observed in spite of the preoperatively prolonged lack of appropriate arterial perfusion (last dialysis, 11 (th) POD / discharge, 18 (th) POD). At 3 months postoperatively, the patient reported an increase of his body weight of 8 kg (at 6 months, 20 kg; improved but still elevated laboratory parameters indicating renal insufficiency; RR within normal range). Postinterventional MR angiography revealed a regular perfusion of the bifurcational prosthesis and of the bypasses to the superior mesenteric and left renal arteries.
This exemplary case demonstrates impressively the individual therapeutic chances, options and the potential in the diagnostic and therapeutic interdisciplinary management and its combined expertise. The clinical course in this case indicates that the assessment of the arterial blood supply has to be included in the diagnostic of an acute renal insufficiency associated with anuria. If there is a minimal residual perfusion, which might just be sufficient for maintenance of structural integrity, there is a real chance for a restitution of renal function after successful revascularisation.
基于一份关于一名几乎无症状的肠系膜上动脉主动脉闭塞患者的特殊病例报告,描述了通过一项技术要求高的血管外科手术干预以及随后的强化医疗和肾脏护理所实现的成功治疗及良好预后,包括肾功能几乎恢复正常(除了适当的诊断和手术策略)。
在一名49岁男性患者中,诊断出在腹腔干分支下方的“高位”主动脉闭塞,通过第4至6肋间动脉的动脉侧支为腹部和下肢提供动脉灌注。双侧肾动脉闭塞,导致连续性肾功能不全,需要透析以及肾血管性高血压。然而,可检测到左肾实质有残余灌注。治疗措施包括在血液透析及伴随的抗高血压药物治疗后,进行开放的腹腔干上方主动脉双股人工血管植入、左肾动脉血管重建(人工血管搭桥)以及人工血管肠系膜上动脉搭桥植入。术后,尽管术前长期缺乏适当的动脉灌注(最后一次透析,术后第11天/出院,术后第18天),但仍观察到肾灌注得以重建。术后3个月,患者报告体重增加了8千克(6个月时增加了20千克;实验室参数有所改善但仍表明存在肾功能不全;呼吸频率在正常范围内)。介入后磁共振血管造影显示双叉人工血管以及肠系膜上动脉和左肾动脉搭桥的灌注正常。
这个典型病例令人印象深刻地展示了个体治疗机会、选择以及诊断和治疗跨学科管理及其综合专业知识的潜力。该病例的临床过程表明,在诊断与无尿相关的急性肾功能不全时,必须评估动脉血供情况。如果存在最小限度的残余灌注,这可能刚好足以维持结构完整性,那么在成功进行血管重建后,肾功能就有真正恢复的机会。