白细胞介素-2诱导型T细胞激酶（ITK）找到了另一个（舞蹈）伙伴……TFII-I。
IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I.
作者信息
August Avery
机构信息
Center for Molecular Immunology & Infectious Disease, Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, PA 16802, USA.
出版信息
Eur J Immunol. 2009 Sep;39(9):2354-7. doi: 10.1002/eji.200939813.
Abstract
The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2- inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.
摘要
调节T细胞活化的信号已经研究了一段时间。我们知道，TCR与抗原/MHC复合物相互作用后，会触发包括酪氨酸激酶和丝氨酸/苏氨酸激酶在内的多种激酶的活化。Tec家族激酶白细胞介素-2诱导型T细胞激酶（ITK）在这一反应中发挥作用，但ITK调节的信号通路却鲜为人知。ITK的结合伴侣和底物更是知之甚少。本期《欧洲免疫学杂志》上的一篇论文表明ITK与转录调节因子TFII-I相互作用，从而扩展了我们在这一领域的认识。本文将讨论这一发现的意义。
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本文引用的文献
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2
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Blood. 2009 Jul 16;114(3):564-71. doi: 10.1182/blood-2008-12-196345. Epub 2009 May 14.
3
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.因白细胞介素-2诱导型T细胞激酶突变而纯合的女孩，该突变导致蛋白质缺乏，她们会发展出致命的与EB病毒相关的淋巴细胞增殖。
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