Langer Seppo W, Sehested Maxwell, Jensen Peter Buhl
Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Tumori. 2009 May-Jun;95(3):273-82. doi: 10.1177/030089160909500301.
An accidental extravasation of anthracycline-containing chemotherapy is a feared complication that may lead to necrosis and severe tissue destruction. For four decades, much effort has been done to prevent and treat this devastating condition. Savene has recently been proved to be very effective, and is the only approved treatment against anthracyline extravasation. It is thus now widely recommended. The present article represents a comprehensive review of, and historical insight to, the experimental and clinical studies of surgical and non-surgical treatments of extravasation during forty years of clinical anthracycline treatment.
含蒽环类药物的化疗意外外渗是一种令人担忧的并发症，可能导致坏死和严重的组织破坏。四十年来，人们为预防和治疗这种毁灭性疾病付出了巨大努力。Savene最近被证明非常有效，是唯一被批准用于治疗蒽环类药物外渗的药物。因此，它现在被广泛推荐。本文全面回顾了四十年来临床蒽环类药物治疗期间外渗的手术和非手术治疗的实验和临床研究，并提供了历史见解。
