[FABP2 Ala54Thr基因多态性与非酒精性脂肪性肝病风险的关系研究]

[Study on the relationship between FABP2 Ala54Thr polymorphism and the risk of non-alcoholic fatty liver diseases].

作者信息

Peng Xian'e, Zhang Ling, Wang Qingqing, Cui Xu

机构信息

School of Public Health, Fujian Medical University, Fuzhou 350004, China.

出版信息

Wei Sheng Yan Jiu. 2009 Jul;38(4):401-4.

PMID:19689066

Abstract

OBJECTIVE

To explore the relationship between FABP2 Ala54Thr polymorphism and the risk of non-alcoholic fatty liver diseases (NFLD).

METHODS

A hospital-based case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect FABP2 Ala54Thr genotypes. The cases and controls were interviewed by using the same questionnaire.

RESULTS

The genotype frequencies of Ala54Ala, Ala54Thr and Thr54Thr were 39.7%, 46.6% and 13.7% in cases, and 48.5%, 43.1% and 8.4% in controls. The Thr allele frequency in cases (36.97%) was higher than that in the controls (29.94%)(P = 0.01). Multiple logistic regression results showed that after adjusting other confound factors, the Thr54 Thr genotype was the independent risk factor of NFLD (OR = 1.97, 95% CI: 1.18-3.35).

CONCLUSION

FABP2 Thr54Thr genotype might increase the risk of NFLD development.

摘要

目的

探讨脂肪酸结合蛋白2（FABP2）Ala54Thr多态性与非酒精性脂肪性肝病（NFLD）风险之间的关系。

方法

开展一项基于医院的病例对照研究，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测FABP2 Ala54Thr基因型。通过相同问卷对病例组和对照组进行访谈。

结果

病例组中Ala54Ala、Ala54Thr和Thr54Thr的基因型频率分别为39.7%、46.6%和13.7%，对照组中分别为48.5%、43.1%和8.4%。病例组中Thr等位基因频率（36.97%）高于对照组（29.94%）（P = 0.01）。多因素logistic回归结果显示，在调整其他混杂因素后，Thr54 Thr基因型是非酒精性脂肪性肝病的独立危险因素（OR = 1.97，95%CI：1.18 - 3.35）。