An Daizhi, Wu Shengming, Wei Jingyu, Yang Jijun
Department of Nutrition, Institute of Hygiene and Environmental Medicine, Tianjin 300050, China.
Wei Sheng Yan Jiu. 2009 Jul;38(4):417-9.
To analyse the plasma contents of querceitn and its metabolites in portal vein in rats.
Male Wistar rats were orally administrated with quercetin at the dose of 40 mg/kg. The blood samples were corrected from the portal vein 1 h later. The quercetin and its metabolites in plasma were analysed with high performance liquid chromatography-mass spetrometry (HPLC-MS) method.
The quercetin, quercetin-3-glucuronide, quercetin glucuronide sulfate, 3'-O-methylated quercetin, 4'-O- methylated quercetin and quercetin sulfate were detected in portal vein.
The results indicated that the quercetin was extensively metabolized in intestine and entered the portal vein in various forms after administration.
分析大鼠门静脉中槲皮素及其代谢产物的血浆含量。
以40mg/kg的剂量给雄性Wistar大鼠口服槲皮素。1小时后从门静脉采集血样。采用高效液相色谱-质谱联用（HPLC-MS）法分析血浆中的槲皮素及其代谢产物。
在门静脉中检测到槲皮素、槲皮素-3-葡萄糖醛酸苷、槲皮素硫酸葡萄糖醛酸苷、3'-O-甲基化槲皮素、4'-O-甲基化槲皮素和槲皮素硫酸盐。
结果表明，槲皮素在肠道中被广泛代谢，并在给药后以多种形式进入门静脉。
