Puntarulo S, Galleano M
Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Mini Rev Med Chem. 2009 Aug;9(9):1136-46. doi: 10.2174/138955709788922674.
Iron is essential for human life, however it can be toxic through Fe ability to generate oxygen-derived radicals. This work reviews the main features of Fe binding in the cell and its association to these processes. The chemical nature of the Fe extracted by chelation therapy in pathophysiological situations is also analyzed.
铁对人类生命至关重要，然而，由于铁具有产生氧衍生自由基的能力，它可能具有毒性。本文综述了细胞中铁结合的主要特征及其与这些过程的关联。同时也分析了病理生理情况下螯合疗法所提取的铁的化学性质。
