Yasar Sirin, Mansur Ayse Tulin, Serdar Zehra Asiran, Goktay Fatih, Aslan Canan
Dermatology Department, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Pediatr Dermatol. 2009 Jul-Aug;26(4):465-8. doi: 10.1111/j.1525-1470.2009.00954.x.
Focal epithelial hyperplasia (Heck disease) is a rare disorder caused by specific types of HPV. It mainly involves oral mucosa and children are affected more frequently. It may persist for years, producing a significant reduction in quality of life. Several treatment modalities such as surgical excision, laser ablation, cryotherapy, electrocauterization, topical, intralesional, systemic interferon, and systemic retinoic acid have been used with inconsistent results and many side effects. Here we report three children of Turkish origin with focal epithelial hyperplasia successfully treated with imiquimod 5% cream. No serious side effects were observed and recurrence did not occur during the 1-year follow-up period.
局灶性上皮增生（赫克病）是一种由特定类型人乳头瘤病毒（HPV）引起的罕见疾病。它主要累及口腔黏膜，儿童更易受影响。该病可能持续数年，导致生活质量显著下降。已经采用了多种治疗方式，如手术切除、激光消融、冷冻疗法、电灼术、局部用药、病灶内注射、全身使用干扰素和全身使用维甲酸，但效果不一且有许多副作用。在此，我们报告3名来自土耳其的患有局灶性上皮增生的儿童，使用5%咪喹莫特乳膏成功治愈。在1年的随访期内未观察到严重副作用，也未出现复发。
