在 HLA-A、B 和 DR 相同的家族内骨髓移植中进行 HLA-DP 基因分型。
HLA-DP genotyping in HLA-A,B, and DR identical intrafamilial bone marrow transplantation.
作者信息
al-Daccak R, Loiseau P, Soulie A, Varrin F, Rabian C, Raffoux C, Cohen D, Degos L, Gluckman E, Colombani J
机构信息
Laboratoire d'Histocompatibilité et d'Immunologie, Hôpital Saint-Louis, Paris, France.
出版信息
Leukemia. 1990 Mar;4(3):222-6.
In a study carried out for patients receiving intrafamilial HLA-A,B,DR identical, MLC negative bone marrow transplants, RFLP profiles of HLA-class II for 27 donor recipient pairs were analyzed. Twenty-four pairs were found HLA-class II identical while three pairs were HLA-DP incompatible. The patients of these three pairs did not reveal any acute GVHD greater than or equal to grade II. The seven cases of acute GVHD greater than or equal to grade II found in our panel were HLA-DR, DQ, and DP compatible. Thus, in practical terms pretransplantation HLA-DP typing does not seem necessary for intrafamilial HLA-identical, MLC negative BMT. On the other hand, this work confirmed that it is possible to type for HLA-DP using molecular biological techniques, and this in itself may have some important implications for unrelated BMT.
在一项针对接受家族内 HLA - A、B、DR 相同、混合淋巴细胞培养阴性骨髓移植患者的研究中，分析了 27 对供受者的 HLA - II 类限制性片段长度多态性（RFLP）图谱。发现 24 对 HLA - II 类相同，而 3 对 HLA - DP 不相容。这 3 对患者未出现任何大于或等于 II 级的急性移植物抗宿主病（GVHD）。在我们的研究组中发现的 7 例大于或等于 II 级的急性 GVHD 患者 HLA - DR、DQ 和 DP 是相容的。因此，实际上对于家族内 HLA 相同、混合淋巴细胞培养阴性的骨髓移植，移植前 HLA - DP 分型似乎没有必要。另一方面，这项工作证实了使用分子生物学技术对 HLA - DP 进行分型是可行的，而这本身可能对非亲缘骨髓移植有一些重要意义。
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