Department of Toxicology, Dermato-Cosmetology and Pharmacognosy, Vrije Universiteit Brussel, BE-1090 Brussels, Belgium.
Skin Pharmacol Physiol. 2009;22(5):258-65. doi: 10.1159/000235553. Epub 2009 Aug 18.
Hydrocolloid patches are developed with 10, 20 and 30% (w/w) glycerol as the main active ingredient. By making use of two experimental forearm models, skin efficacy and its dependency on the glycerol concentration applied were compared with a blank reference patch, a commercialized protective patch and a cosmetic barrier cream. Skin hydration and transepidermal water loss measurements were combined with skin erythema assessments. After a single application to healthy skin, a clear concentration-dependent effect of glycerol-containing patches was observed with - for the highest glycerol content - a 31% increase in skin hydration and an improvement in skin barrier properties of 15%. This glycerol-containing patch also accelerated barrier recovery of mechanically irritated skin after stripping with cyanoacrylate tape. After 7 days of repetitive application, a significantly hydrating effect of the 30% glycerol-containing patch was observed, which was of the same order of magnitude as observed for the cosmetic barrier cream, the latter being applied twice daily. The effects seen were maximal after 3 days of patch application.
水胶体贴片以 10%、20%和 30%（w/w）甘油作为主要活性成分开发而成。通过使用两个实验性前臂模型，将皮肤功效及其对应用的甘油浓度的依赖性与空白参考贴片、商业化的保护贴片和化妆品屏障霜进行了比较。皮肤水合作用和经表皮水分损失测量与皮肤红斑评估相结合。单次应用于健康皮肤后，观察到含有甘油的贴片具有明显的浓度依赖性效应 - 对于最高甘油含量 - 皮肤水合作用增加 31%，皮肤屏障特性改善 15%。这种含有甘油的贴片还加速了用氰基丙烯酸酯胶带剥离后的机械刺激皮肤的屏障恢复。重复应用 7 天后，观察到 30%甘油贴片具有显著的保湿效果，与每天应用两次的化妆品屏障霜相当。贴片应用 3 天后效果达到最大。
