Tetteroo G W, Wagenvoort J H, Castelein A, Tilanus H W, Ince C, Bruining H A
Department of Surgery, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
Lancet. 1990 Mar 24;335(8691):704-7. doi: 10.1016/0140-6736(90)90813-k.
181 patients undergoing resection of the oesophagus for carcinoma were randomised to receive selective decontamination (test group) or conventional perioperative antibiotic prophylaxis (controls). 114 patients were finally included in the study: 12 of 56 test patients had 18 infections, whereas 32 of 58 controls acquired 51 infections. Colonisation with aerobic gram-negative microorganisms, and the number of postoperative respiratory tract infections were significantly lower in the test patients. The postoperative therapeutic use of antibiotics was significantly lower in the test group. No endogenous infections were caused by gram-negative bacilli in the test group. Selective decontamination reduces colonisation with gram-negative bacilli and postoperative infections after resection of the oesophagus.
181例因食管癌接受食管切除术的患者被随机分为两组，分别接受选择性去污（试验组）或传统围手术期抗生素预防（对照组）。最终114例患者纳入研究：56例试验组患者中有12例发生18次感染，而58例对照组患者中有32例发生51次感染。试验组患者需氧革兰氏阴性微生物定植及术后呼吸道感染次数显著更低。试验组术后抗生素的治疗性使用显著更少。试验组未发生革兰氏阴性杆菌引起的内源性感染。选择性去污可减少食管切除术后革兰氏阴性杆菌定植及术后感染。
