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2
Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer.全球 SRC-1 转录组特征分析鉴定 ADAM22 为内分泌抵抗型乳腺癌的 ER 非依赖性介质。
Cancer Res. 2012 Jan 1;72(1):220-9. doi: 10.1158/0008-5472.CAN-11-1976. Epub 2011 Nov 9.
3
An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models.祖细胞群体失衡反映了乳腺癌原代培养模型中的肿瘤进展。
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4
Methods in Mammary Gland Development and Cancer: the second ENDBC meeting--intravital imaging, genomics, modeling and metastasis.乳腺发育和癌症的方法：第二次 ENDBC 会议——活体成像、基因组学、建模和转移。
Breast Cancer Res. 2010;12(5):311. doi: 10.1186/bcr2630. Epub 2010 Sep 9.

本文引用的文献

1
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis.Lrig1的表达定义了哺乳动物表皮中一个独特的多能干细胞群体。
Cell Stem Cell. 2009 May 8;4(5):427-39. doi: 10.1016/j.stem.2009.04.014.
2
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.乳腺癌细胞系包含具有转移能力和独特分子特征的功能性癌症干细胞。
Cancer Res. 2009 Feb 15;69(4):1302-13. doi: 10.1158/0008-5472.CAN-08-2741. Epub 2009 Feb 3.
3
Efficient tumour formation by single human melanoma cells.单个人类黑色素瘤细胞高效形成肿瘤
Nature. 2008 Dec 4;456(7222):593-8. doi: 10.1038/nature07567.
4
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.BRCA1缺陷型乳腺肿瘤对PARP抑制剂AZD2281单独使用以及与铂类药物联合使用具有高度敏感性。
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84. doi: 10.1073/pnas.0806092105. Epub 2008 Oct 29.
5
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells.乳腺上皮基底区β1整合素缺失会影响干细胞。
Nat Cell Biol. 2008 Jun;10(6):716-22. doi: 10.1038/ncb1734. Epub 2008 May 11.
6
Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue.福尔马林固定石蜡包埋（FFPE）组织的多重免疫荧光标记
BMC Cell Biol. 2008 Mar 19;9:13. doi: 10.1186/1471-2121-9-13.
7
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.在遗传性乳腺癌条件性小鼠模型中对乳腺肿瘤进行化疗耐药的选择性诱导。
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12117-22. doi: 10.1073/pnas.0702955104. Epub 2007 Jul 11.
8
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.小鼠中BRCA1和p53的体细胞缺失会诱发具有人类BRCA1突变基底样乳腺癌特征的乳腺肿瘤。
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6. doi: 10.1073/pnas.0702969104. Epub 2007 Jul 11.
9
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.乳腺中雌激素受体表达与体内干细胞活性的解离。
J Cell Biol. 2007 Jan 1;176(1):19-26. doi: 10.1083/jcb.200604065. Epub 2006 Dec 26.
10
Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.人表皮干细胞和过渡放大细胞的单细胞表达谱分析：Lrig1是干细胞静止的调节因子。
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细节决定一切：乳腺发育与癌症的研究方法。

It's all in the details: methods in breast development and cancer.

机构信息

Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstr, 66; CH-4058 Basel, Switzerland.

出版信息

Breast Cancer Res. 2009;11(4):305. doi: 10.1186/bcr2346. Epub 2009 Aug 14.

DOI:10.1186/bcr2346
PMID:19691817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2750118/
Abstract

The inaugural European Network for Breast Development and Cancer (ENBDC) meeting on 'Methods in Mammary Gland Development and Cancer' was held in Weggis, Switzerland last April. The goal was to discuss the details of techniques used to study mammary gland biology and tumourigenesis. Highlights of this meeting included the use of four-colour fluorescence for protein co-localisation in tissue microarrays, genome analysis at single cell resolution, technical issues in the isolation of normal and tumour stem cells, and the use of mouse models and mammary gland transplantations to elucidate gene function in mammary development and to study drug resistance in breast cancer.

摘要

去年四月，首届“乳腺发育与癌症欧洲网络（ENBDC）”会议在瑞士韦吉斯召开，会议主题为“乳腺发育与癌症研究方法”。会议旨在讨论研究乳腺生物学和肿瘤发生的技术细节。本次会议的重点包括使用四色荧光技术进行组织微阵列中的蛋白质共定位分析、单细胞分辨率下的基因组分析、正常和肿瘤干细胞分离中的技术问题、以及利用小鼠模型和乳腺移植来阐明乳腺发育中的基因功能和研究乳腺癌中的药物耐药性。