Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China.
Eur J Radiol. 2011 Feb;77(2):269-73. doi: 10.1016/j.ejrad.2009.07.032. Epub 2009 Aug 18.
To investigate the abnormal diffusion in cerebral white matter and its relationship with the olfactory dysfunction in patients with Parkinson's disease (PD) through diffusion tensor imaging (DTI).
Diffusion tensor imaging of the cerebrum was performed in 25 patients with Parkinson's disease and 25 control subjects matched for age and sex. Differences in fractional anisotropy (FA) and mean diffusivity (MD) between these two groups were studied by voxel-based analysis of the DTI data. Correlations between diffusion indices and the olfactory function in PD patients were evaluated using the multiple regression model after controlling for the duration of the disease, Unified Parkinson's Disease Rating Sale (UPDRS), and age.
The damaged white and gray matter showed decreased FA or increased MD, localized bilaterally in the cerebellar and orbitofrontal cortex. In addition, in PD patients there was a positive correlation between FA values in the white matter of the left cerebellum and the thresholds of olfactory identification (TOI) and a negative correlation between MD values in the white matter of right cerebellum and the TOI.
In patients with PD, there was disruption in the cerebellar white matter which may play an important role in the olfactory dysfunction in patients with Parkinson's disease.
通过弥散张量成像（DTI）研究帕金森病（PD）患者脑白质弥散异常及其与嗅觉功能障碍的关系。
对 25 例帕金森病患者和 25 例年龄和性别相匹配的对照组进行大脑弥散张量成像。通过对 DTI 数据进行基于体素的分析，研究两组间各向异性分数（FA）和平均弥散度（MD）的差异。采用多元回归模型，在控制疾病持续时间、帕金森病统一评定量表（UPDRS）和年龄的情况下，评估扩散指标与 PD 患者嗅觉功能之间的相关性。
受损的白质和灰质显示 FA 值降低或 MD 值升高，双侧对称分布于小脑和眶额皮质。此外，PD 患者左侧小脑白质 FA 值与嗅觉识别阈值（TOI）呈正相关，右侧小脑白质 MD 值与 TOI 呈负相关。
PD 患者小脑白质存在破坏，可能在帕金森病患者嗅觉功能障碍中起重要作用。
