Roesgen M, Hierholzer G
Berufsgenossenschaftliche Unfallklinik Duisburg-Buchholz.
Aktuelle Traumatol. 1990 Feb;20(1):37-43.
To investigate the regeneration of human bone in a good and firm layer, a new model is introduced. It has been developed by us because of therapeutical necessity, but then is continued in the course of further investigations independent from further therapeutical procedure. We use the iliac crest as a bony layer for implants that are the object of research. For the therapy in cases of delayed bone healing, pseudarthrosis, bony defect or corrective osteotomy, the cancellous bone is removed. The empty iliac crest is then filled up with material we intend to investigate. On the occasion of further operations that became necessary because of the underlying bone disease, we had an opportunity to obtain sample of bone and material by hole-drilling through the iliac crest. The bony cylinder can be examined by histological technique. We used this procedure on 105 patients up to now. There were no specific complications caused by this technique at the iliac crest. 37 biopsies could be taken and will now be examined. In future it may be possible to incorporate new bone in this layer for a further therapy and to fill up the lost donor sites.
为了研究人类骨骼在良好且稳固层面的再生情况，引入了一种新模型。它是我们基于治疗需求而开发的，但随后在进一步研究过程中得以持续，且与后续治疗程序无关。我们使用髂嵴作为植入物的骨层，而这些植入物是研究对象。对于骨愈合延迟、假关节、骨缺损或矫正截骨术等病例的治疗，要去除松质骨。然后用我们打算研究的材料填充空的髂嵴。由于潜在的骨病而需要进行进一步手术时，我们有机会通过在髂嵴上钻孔获取骨和材料样本。骨圆柱体可通过组织学技术进行检查。到目前为止，我们已对105名患者采用了此程序。该技术在髂嵴处未引发特定并发症。可以进行37次活检，现在将对其进行检查。未来有可能在该层面纳入新骨以进行进一步治疗，并填补失去的供骨部位。
