用苦瓜粗过氧化物酶由二氢白藜芦醇生物催化生产无环双[联苄] 。
Biocatalytic production of acyclic bis[bibenzyls] from dihydroresveratrol by crude Momordica charantia peroxidase.
作者信息
Xie Chun-Feng, Yuan Hui-Qing, Qu Jian-Bo, Xing Jie, Lü Bei-Bei, Wang Xiao-Ning, Ji Mei, Lou Hong-Xiang
机构信息
School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.
出版信息
Chem Biodivers. 2009 Aug;6(8):1193-201. doi: 10.1002/cbdv.200800229.
Biotransformation of dihydroresveratrol by crude Momordica charantia peroxidase provided six new acyclic bis[bibenzyls] 1-6. Their structures were established on the basis of NMR and MS analyses as C-C, C-O-C, and C-CH(2)-C dimers of dihydroresveratrol. Compounds 1-6 were tested for antiproliferative activity against human prostate cancer PC3 cell line in vitro, and 2 and 6 were found to be more potent than the parent compound.
苦瓜粗过氧化物酶对二氢白藜芦醇的生物转化产生了六种新的无环双[联苄]化合物1-6。根据核磁共振（NMR）和质谱（MS）分析确定了它们的结构，为二氢白藜芦醇的C-C、C-O-C和C-CH(2)-C二聚体。对化合物1-6进行了体外抗人前列腺癌PC3细胞系增殖活性测试，发现化合物2和6比母体化合物更具活性。
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