Seki Takayuki, Ito Tateki, Kawachi Hiroshi, Sekine Masaki, Funata Nobuaki, Takizawa Touichiro
Department of Molecular Pathophysiology, Graduated School of Allied Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
J Med Dent Sci. 2009 Mar;56(1):25-35.
The intramucosal lesion of gastric signet ring cell carcinoma (SIG) is known to form a layered structure (LS) that simulates mucin expression in ordinary gastric mucosa. In this study, we suspected the influence of background mucosa on the formation of LS and performed histopathological analysis. We examined 35 cases of intramucosal SIG with a maximum diameter of 30 mm or less. The LS patterns were classified into those with a layer of MUC6-positive cells (complete pattern, CP) and those lacking this layer (incomplete pattern, ICP). The relationship between LS patterns and the characteristics of the background mucosa, the expression of MUC2 (intestinal-type mucin antigen), MUC5AC (foveolar-type mucin antigen), and Ki-67 (the marker of cell proliferation activity) was examined by histochemistry and immunohistochemistry. Intestinal metaplasia in the background mucosa and MUC2 expression were frequently observed in cases with ICP. Ki-67-positive cells were much more and they were distributed more widely in the lesion of cases with ICP alone than in the other cases. Mucin expression and LS formation of gastric SIG are strongly influenced by its background mucosa. The cases completely lacking MUC6 expression may have higher malignant potential.
胃印戒细胞癌（SIG）的黏膜内病变已知会形成一种分层结构（LS），这种结构模拟了普通胃黏膜中的黏蛋白表达。在本研究中，我们怀疑背景黏膜对LS形成的影响，并进行了组织病理学分析。我们检查了35例最大直径为30mm或更小的黏膜内SIG。LS模式分为有一层MUC6阳性细胞的模式（完整模式，CP）和缺乏该层的模式（不完整模式，ICP）。通过组织化学和免疫组织化学检查了LS模式与背景黏膜特征、MUC2（肠型黏蛋白抗原）、MUC5AC（胃小凹型黏蛋白抗原）和Ki-67（细胞增殖活性标志物）表达之间的关系。在ICP病例中，背景黏膜中的肠化生和MUC2表达经常被观察到。单独ICP病例的病变中Ki-67阳性细胞更多且分布更广泛。胃SIG的黏蛋白表达和LS形成受到其背景黏膜的强烈影响。完全缺乏MUC6表达的病例可能具有更高的恶性潜能。
