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[一例由鲍曼不动杆菌引起的暴发性社区获得性肺炎尸检病例]

[An autopsy case of fulminant community-acquired pneumonia due to Acinetobacter baumannii].

作者信息

Koshimizu Naoki, Sato Masaki, Gemma Hitoshi, Uemura Keiichi, Chida Kingo

机构信息

Department of Respiratory Medicine, Fukuroi Municipal Hospital.

出版信息

Kansenshogaku Zasshi. 2009 Jul;83(4):392-7. doi: 10.11150/kansenshogakuzasshi.83.392.

Abstract

A 73-year-old man with underlying chronic renal failure, angina pectoris, chronic heart failure, and respiratory failure reporting three-day appetite loss, fever, and drowsiness was admitted for lower right lung pneumonia. Despite antibiotic administration, infiltration progressed to the entire right lung and upper left lung after 12 hours, and he developed acute respiratory distress syndrome (ARDS) and multiple organ failure. Respirator ventilation and continuous hemodiafiltration (CHDF) failed to halt this progression and he died on hospital day 3. Acinetobacter baumannii was cultured from bronchoalveolar lavage fluid and the postmortem lung specimen, indicating that his severe community-acquired pneumonia was due to A. baumannii. Microscopically, the lung specimen showed prominent cellular alveolar exudate and partial hyaline membrane with suppurative pneumonia. Although A. baumannii is considered the causative agent in nosocomical pneumonia, community-acquired pneumonia due to A. baumannii is very rare. This is, to our knowledge, the first report in Japan. In the subtropical zone, A. baumannii is recognized as an important cause of severe community-acquired pneumonia. Given the apparent progress of global warming, physicians in Japan would do well to familiarize themselves with subtropical disease causes such A. baumannii when managing severe community-acquired pneumonia.

摘要

一名73岁男性,有慢性肾衰竭、心绞痛、慢性心力衰竭和呼吸衰竭病史,因食欲减退、发热和嗜睡3天入院,诊断为右下肺炎。尽管使用了抗生素,但12小时后肺部浸润进展至整个右肺及左上肺,患者发展为急性呼吸窘迫综合征(ARDS)和多器官功能衰竭。机械通气和持续血液透析滤过(CHDF)未能阻止病情进展,患者于住院第3天死亡。支气管肺泡灌洗液和尸检肺标本培养出鲍曼不动杆菌,提示其严重的社区获得性肺炎由鲍曼不动杆菌引起。显微镜下,肺标本显示明显的细胞性肺泡渗出物和部分透明膜,伴有化脓性肺炎。尽管鲍曼不动杆菌被认为是医院获得性肺炎的病原体,但由鲍曼不动杆菌引起的社区获得性肺炎非常罕见。据我们所知,这是日本的首例报告。在亚热带地区,鲍曼不动杆菌被认为是严重社区获得性肺炎的重要病因。鉴于全球变暖的明显进展,日本医生在处理严重社区获得性肺炎时,最好熟悉像鲍曼不动杆菌这样的亚热带疾病病因。

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