Brotman A W, McCormick S
Department of Psychiatry, Massachusetts General Hospital, Erich Lindeman Mental Health Center, Boston.
J Clin Psychiatry. 1990 Apr;51(4):164-6.
The authors present a series of cases demonstrating that some chronically psychotic patients require higher doses of antipsychotic medication (greater than 15 mg/day of haloperidol equivalents) than are currently in vogue as a result of research on low-dose treatment. In a random sample of 100 patients treated with psychotropic medication, 64 were treated with antipsychotics. Of these, 8 (12.5%) appeared to require high doses. The literature on low-dose treatment is reviewed, and the role of higher-dose therapy is placed in perspective.
