Bonardel G, Chargari C, Gontier E, Bauduceau O, Soret M, Dechaud C, Fayolle M, Foehrenbach H
Service de Médecine Nucléaire, Hôpital d'Instruction des Armées du Val-de-Grâce, 75230 Paris cedex 05, France.
Cancer Radiother. 2009 Oct;13(6-7):490-8. doi: 10.1016/j.canrad.2009.06.016. Epub 2009 Aug 20.
Since its introduction in clinical practice in the 1990's, positron emission tomography (PET), usually with (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG), has become an important imaging modality in patients with cancer. For cervix carcinoma, FDG-PET is significantly more accurate than computed tomography (CT) and is recommended for loco-regional lymph node and extrapelvic staging. The metabolic dimension of the technique provides additional prognostic information. Ongoing studies now concentrate on more advanced clinical applications, such as the planning of radiotherapy, the response evaluation after the induction of therapy, the early detection of recurrence. Technical innovations, such as PET cameras with better spatial resolution and hybrid positron emission tomography/computed tomography (PET-CT), available now on the whole territory, provide both anatomic and metabolic information in the same procedure. From the point of view of biological metabolism, new radiopharmaceutical probes are being developed. Those hold promise for future refinements in this field. This article reviews the current applications of FDG-PET in patients with cervix cancer.
自20世纪90年代正电子发射断层扫描（PET），通常是使用（18）F-氟-2-脱氧-D-葡萄糖（（18）F-FDG）被引入临床实践以来，它已成为癌症患者重要的成像方式。对于宫颈癌，FDG-PET比计算机断层扫描（CT）显著更准确，推荐用于局部区域淋巴结和盆腔外分期。该技术的代谢维度提供了额外的预后信息。目前正在进行的研究集中在更先进的临床应用上，如放射治疗的规划、诱导治疗后的反应评估、复发的早期检测。技术创新，如现在在整个领域都可用的具有更好空间分辨率的PET相机以及正电子发射断层扫描/计算机断层扫描（PET-CT）一体机，在同一程序中提供解剖和代谢信息。从生物代谢的角度来看，正在开发新的放射性药物探针。这些为该领域未来的改进带来了希望。本文综述了FDG-PET在宫颈癌患者中的当前应用。
