Brownlie Rebecca, Zamoyska Rose
Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh EH9 3JT, UK.
Immunity. 2009 Aug 21;31(2):174-6. doi: 10.1016/j.immuni.2009.08.002.
Mutations in the adaptor molecule LAT can lead to autoimmunity. In this issue of Immunity, Mingueneau et al. (2009) describe how this may not be a failure of central tolerance.
衔接分子LAT中的突变可导致自身免疫。在本期《免疫》杂志中,明盖诺等人(2009年)描述了这种情况可能并非中枢耐受失败。