Laboratório de Interação Neuro-Humoral, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Av. Sarmento Leite 500, Porto Alegre, Rio Grande do Sul, Brazil.
Steroids. 2009 Nov-Dec;74(13-14):1045-50. doi: 10.1016/j.steroids.2009.08.005. Epub 2009 Aug 20.
The secretion of DHEA-synthesized mainly in the adrenal cortex-increases in the postnatal aging, peaks in the twenties and decreases with age afterwards. Exogenous DHEA can exert a dual effect depending on dose and on tissue. Akt is a serine/threonine kinase whose activity has been seen as an interventional approach for cardiomyopathic damage resulting from aging changes. In order to evaluate DHEA effects over myocardial Akt protein expression associated to oxidative stress markers during aging, male Wistar rats (3 and 18 months) were assigned into two groups: control or DHEA (10mg/kg, subcutaneously, for 5 weeks). In the aged group, we found increased lipid peroxidation and glutathione-S-transferase activity. DHEA produced an increase in p-Akt protein expression and a decrease in SOD activity in both ages. Akt pathway activation might be related to changes in oxidative stress parameters according to age.
脱氢表雄酮（DHEA）主要由肾上腺皮质分泌，在出生后会逐渐增加，在二十多岁时达到峰值，随后随着年龄的增长而下降。外源性 DHEA 可以根据剂量和组织发挥双重作用。Akt 是一种丝氨酸/苏氨酸激酶，其活性已被视为干预衰老引起的心肌病损伤的一种方法。为了评估 DHEA 对与氧化应激标志物相关的心肌 Akt 蛋白表达的影响，雄性 Wistar 大鼠（3 个月和 18 个月）分为两组：对照组或 DHEA 组（10mg/kg，皮下，5 周）。在老年组中，我们发现脂质过氧化和谷胱甘肽-S-转移酶活性增加。DHEA 在两个年龄段均增加了 p-Akt 蛋白表达，降低了 SOD 活性。Akt 通路的激活可能与根据年龄变化的氧化应激参数有关。
