非编码 RNA 转录本：神经元应激的传感器、突触可塑性的调节剂，以及阿尔茨海默病发病的改变因子。
Non-coding RNA transcripts: sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease.
机构信息
Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA.
出版信息
Neurosci Lett. 2009 Dec 4;466(2):81-8. doi: 10.1016/j.neulet.2009.08.032. Epub 2009 Aug 20.
Abstract
Non-protein-coding RNAs (ncRNAs) play critical roles on many levels of cellular information processing and pervasive expression of ncRNAs in the nervous system could help explain brain complexity. NcRNAs are enriched in the central nervous system and are associated with specific neuroanatomical regions. Additionally, several recent publications have revealed an important role for deregulation of ncRNAs in various human neuropathologies, such as Alzheimer's disease, Parkinson's disease and Fragile X mental retardation. Herein, we summarize reports on functional ncRNA molecules involved in cellular stress response, particularly related to Alzheimer's disease. We conclude that ncRNAs have a prominent role in maintaining precise physiological levels of gene products directly implicated in Alzheimer's disease pathology.
摘要
非蛋白编码 RNA（ncRNA）在细胞信息处理的多个层面上发挥着关键作用，而 ncRNA 在神经系统中的广泛表达有助于解释大脑的复杂性。ncRNA 在中枢神经系统中丰富存在，并与特定的神经解剖区域相关。此外，最近的几项出版物揭示了 ncRNA 失调在各种人类神经病理学中的重要作用，如阿尔茨海默病、帕金森病和脆性 X 智力迟钝。在此，我们总结了涉及细胞应激反应的功能性 ncRNA 分子的报告，特别是与阿尔茨海默病相关的报告。我们的结论是，ncRNA 在维持与阿尔茨海默病病理直接相关的基因产物的精确生理水平方面发挥着重要作用。
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