Washington N, Greaves J L, Wilson C G
Department of Physiology and Pharmacology, Queen's Medical Centre, Nottingham, UK.
J Pharm Pharmacol. 1990 Jan;42(1):50-3. doi: 10.1111/j.2042-7158.1990.tb05348.x.
Gamma scintigraphy was used in twelve healthy volunteers to establish whether the time of dosing of Liquid Gaviscon relative to a meal influenced its therapeutic action. Indium-113m labelled Liquid Gaviscon was administered to fasted subjects, 30 min after a technetium-99m labelled meal or immediately before ingestion of the meal. The time for 50% of the Gaviscon to empty from the stomach was 0.36 +/- 0.13 h, 3.10 +/- 0.31 h and 0.68 +/- 0.04 h (s.e.m.), respectively. The preparation was found to empty rapidly from the fasted stomach and could not be floated on a meal consumed subsequently. For raft formation to occur, Liquid Gaviscon should be taken 30 min after a meal.
对12名健康志愿者进行了γ闪烁扫描，以确定相对于进餐时间服用液状胃仙-U是否会影响其治疗效果。将铟-113m标记的液状胃仙-U给予空腹受试者、在服用锝-99m标记餐食30分钟后或在餐食摄入前立即服用。胃仙-U从胃中排空50%的时间分别为0.36±0.13小时、3.10±0.31小时和0.68±0.04小时（标准误）。发现该制剂在空腹胃中排空迅速，且不能漂浮在随后摄入的餐食上。为了形成筏状物，液状胃仙-U应在进餐后30分钟服用。
