Salim A S
University Department of Surgery, Royal Infirmary, Glasgow, UK.
J Pharm Pharmacol. 1990 Jan;42(1):64-7. doi: 10.1111/j.2042-7158.1990.tb05354.x.
Rats infused for 24 h with pentagastrin (4 micrograms kg-1 min-1) and carbachol (0.8 microgram kg-1 min-1) developed acute duodenal ulceration (100%) and hyperchlorhydria (69 +/- 5.3 mumol h-1 vs 14 +/- 0.9 mumol h-1, P less than 0.001, n = 10). The animals were then given daily by gavage, saline, allopurinol with dimethyl sulphoxide (DMSO) or cysteine with methyl methionine sulphonium bromide (MMSB). Two days after the infusion, 10 rats (100%) given saline and 7 rats (70%) given allopurinol and DMSO, or cysteine and MMSB, showed duodenal ulceration. Five days after the infusion, 8 rats (80%) given saline, 3 rats (30%) given allopurinol and DMSO, and 2 rats (20%) given cysteine and MMSB had duodenal ulceration. Seven days after the infusion, only 5 rats (50%) given saline still had duodenal ulceration. Daily intramuscular injection of reserpine (0.1 mg kg-1) for 6 weeks produced chronic duodenal ulceration (90%) and hyperchlorhydria (47 +/- 3.1 mumol h-1 vs 12 +/- 0.9 mumol h-1, P less than 0.001, n = 10). Animals were then given daily by gavage, saline, allopurinol and DMSO, or cysteine and MMSB. Five days after reserpine, 10 rats (100%) given saline, 8 rats (80%) given allopurinol and DMSO, and 7 rats (70%) given cysteine and MMSB showed duodenal ulceration. Ten days after reserpine, 9 rats (90%) given saline, 3 rats (30%) given allopurinol and DMSO, and 4 rats (40%) given cysteine and MMSB had duodenal ulceration. Fifteen days after reserpine, 8 rats (80%) receiving saline and only one rat (10%) receiving allopurinol and DMSO or cysteine and MMSB had duodenal ulceration.(ABSTRACT TRUNCATED AT 250 WORDS)
用五肽胃泌素（4微克/千克/分钟）和卡巴胆碱（0.8微克/千克/分钟）给大鼠输注24小时后，大鼠出现急性十二指肠溃疡（100%）和胃酸过多（69±5.3微摩尔/小时，而对照组为14±0.9微摩尔/小时，P<0.001，n = 10）。然后，通过灌胃每日给动物给予生理盐水、含二甲亚砜（DMSO）的别嘌呤醇或含甲硫氨酸甲基溴化物（MMSB）的半胱氨酸。输注后两天，给予生理盐水的10只大鼠（100%）、给予别嘌呤醇和DMSO或半胱氨酸和MMSB的7只大鼠（70%）出现十二指肠溃疡。输注后五天，给予生理盐水的8只大鼠（80%）、给予别嘌呤醇和DMSO的3只大鼠（30%）以及给予半胱氨酸和MMSB的2只大鼠（20%）出现十二指肠溃疡。输注后七天，仅给予生理盐水的5只大鼠（50%）仍有十二指肠溃疡。每天肌肉注射利血平（0.1毫克/千克）持续6周会导致慢性十二指肠溃疡（90%）和胃酸过多（47±3.1微摩尔/小时，而对照组为12±0.9微摩尔/小时，P<0.001，n = 10）。然后，通过灌胃每日给动物给予生理盐水、别嘌呤醇和DMSO或半胱氨酸和MMSB。利血平注射后五天，给予生理盐水的10只大鼠（100%）、给予别嘌呤醇和DMSO的8只大鼠（80%）以及给予半胱氨酸和MMSB的7只大鼠（70%）出现十二指肠溃疡。利血平注射后十天，给予生理盐水的9只大鼠（90%）、给予别嘌呤醇和DMSO的3只大鼠（30%）以及给予半胱氨酸和MMSB的4只大鼠（40%）出现十二指肠溃疡。利血平注射后十五天，接受生理盐水的8只大鼠（80%）以及仅接受别嘌呤醇和DMSO或半胱氨酸和MMSB的1只大鼠（10%）出现十二指肠溃疡。（摘要截断于250字）
