作为强效大麻素CB1受体拮抗剂的1,4,5,6-四氢哒嗪的合成与构效关系研究
Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists.
作者信息
Lange Jos H M, den Hartog Arnold P, van der Neut Martina A W, van Vliet Bernard J, Kruse Chris G
机构信息
Solvay Pharmaceuticals, Chemical Design and Synthesis Unit, Research Laboratories, C. J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
出版信息
Bioorg Med Chem Lett. 2009 Oct 1;19(19):5675-8. doi: 10.1016/j.bmcl.2009.08.007. Epub 2009 Aug 7.
PMID:19699640
Abstract
The synthesis and structure-activity relationship studies of 1,4,5,6-tetrahydropyridazines are described. The target compounds 3-5 represent a novel class of potent and selective CB1 receptor antagonists.
摘要
描述了1,4,5,6-四氢哒嗪的合成及其构效关系研究。目标化合物3-5代表了一类新型的强效和选择性CB1受体拮抗剂。
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