Istituto Clinico Humanitas, IRCCS, Department of Immunology and Inflammation, Rozzano, Milan, Italy. cecilia.garlanda@humanitas
Trends Immunol. 2009 Sep;30(9):439-46. doi: 10.1016/j.it.2009.06.001. Epub 2009 Aug 21.
TIR8, also known as single Ig IL-1 receptor (IL-R)-related molecule, SIGIRR, is a member of the IL-1R like (ILR) family. Unlike most other members of this family, it has a single extracellular Ig domain, a long cytoplasmic tail and a Toll/IL-1R (TIR) domain with two amino acid substitutions possibly consistent with non-conventional signaling. The TIR8 structure and pattern of expression are conserved in evolution from birds to humans. Current evidence suggests that TIR8 inhibits signaling receptor complexes of IL-1 family members associated with Th1 (IL-18), Th2 (IL-33) and Th17 (IL-1) differentiation. TIR8 also dampens TLR-mediated activation. The ability to dampen signaling from ILR family members and TLRs makes TIR8 a key regulator of inflammation, cancer-related inflammation, and autoimmunity.
TIR8，也称为单一免疫球蛋白 IL-1 受体（IL-R）相关分子，SIGIRR，是 IL-1R 样（ILR）家族的成员。与该家族的大多数其他成员不同，它具有一个单一的细胞外 Ig 结构域、一个长的细胞质尾巴和一个 Toll/IL-1R（TIR）结构域，其中有两个氨基酸替换可能符合非常规信号传递。TIR8 的结构和表达模式在从鸟类到人类的进化过程中是保守的。目前的证据表明，TIR8 抑制与 Th1（IL-18）、Th2（IL-33）和 Th17（IL-1）分化相关的 IL-1 家族成员的信号转导受体复合物。TIR8 还抑制 TLR 介导的激活。抑制 ILR 家族成员和 TLR 信号传递的能力使 TIR8 成为炎症、癌症相关炎症和自身免疫的关键调节剂。
