Choo H Y, Shin Y O, Park J
Doping Control Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
J Anal Toxicol. 1990 Mar-Apr;14(2):116-9. doi: 10.1093/jat/14.2.116.
When phenothiazine drugs (chlorpromazine, promazine, promethazine, propiomazine, propionylpromazine, trifluoperazine and trimeprazine) were reacted with m-chloroperbenzoic acid, N-demethylated phenothiazines were obtained in moderate yield. The mass spectra of the N-demethylated phenothiazines showed either m/z 44 and 72 or m/z 58 as characteristic ions depending on their side chain. The N-demethylated propiomazine was identified as a metabolite of propiomazine from the urine of a rat which was given propiomazine orally.
