Zamecnik J
Health and Welfare Canada, Bureau of Drug Research, Ottawa, Ontario.
J Anal Toxicol. 1990 Mar-Apr;14(2):132-6. doi: 10.1093/jat/14.2.132.
Gas chromatographic and mass spectrometric properties of cyclic methyl and n-butyl boronates of 13 beta blockers and bronchodilators were investigated for potential use in screening and quantitation in biological materials of interest. The tested compounds included acebutolol, atenolol, labetalol, levobunolol, metoprolol, nadolol, oxprenolol, pindolol, propranolol, sotalol, albuterol, and isoproterenol. The cyclic methyl boronates were superior in gas chromatographic properties to the corresponding n-butylboronates of these compounds. Higher weights of fragments obtained with n-butyl boronation may be advantageous for analyses of complex biological matrices. Mass spectra and retention times relative to SKF-525A are provided.
研究了13种β受体阻滞剂和支气管扩张剂的环状硼酸甲酯和硼酸正丁酯的气相色谱和质谱特性，以探讨其在感兴趣的生物材料筛选和定量分析中的潜在用途。测试的化合物包括醋丁洛尔、阿替洛尔、拉贝洛尔、左布诺洛尔、美托洛尔、纳多洛尔、氧烯洛尔、吲哚洛尔、普萘洛尔、索他洛尔、沙丁胺醇和异丙肾上腺素。这些化合物的环状硼酸甲酯的气相色谱特性优于相应的硼酸正丁酯。硼酸正丁酯化获得的较高碎片质量可能有利于复杂生物基质的分析。提供了相对于SKF-525A的质谱和保留时间。
