Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Clin Chest Med. 2009 Sep;30(3):525-38, ix. doi: 10.1016/j.ccm.2009.05.014.
Medications can significantly increase weight loss compared with placebo in most trials. In general, patients can expect a weight loss of 8% to 10% from baseline provided they adhere to the weight-loss program and take medications regularly. All medications have side effects that need to be considered before initiating treatment, however. For sibutramine, there is an increase in blood pressure and heart rate that may require discontinuation of the drug in a small percentage of patients. For orlistat, the principal side effect is gastrointestinal in origin resulting from the increased activity of the lower bowel. Cannabinoid receptor antagonists, once a promising target, are no longer under study. Other medications are in clinical trials and on their way.
与安慰剂相比，药物在大多数试验中能显著增加体重减轻。一般来说，只要患者坚持减肥计划并定期服药，他们可以预期体重会从基线下降 8%至 10%。然而，所有药物都有副作用，在开始治疗前需要考虑这些副作用。对于西布曲明，会出现血压和心率升高，这可能需要一小部分患者停止使用该药物。对于奥利司他，主要副作用是源于下肠道活动增加的胃肠道来源。大麻素受体拮抗剂曾经是一个有前途的靶点，但已不再研究。其他药物正在临床试验中，并即将推出。
