Oberg Kerby C, Harris Tyler E, Wongworawat Montri D, Wood Virchel E
Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA 92354, USA.
J Hand Surg Am. 2009 Sep;34(7):1298-302. doi: 10.1016/j.jhsa.2009.04.042.
Variation in longitudinal deficiencies is likely related to the timing and duration of an insult during early limb development. In experimental models, teratogenic insults induce ulnar deficiencies earlier in gestation than radial deficiencies. In this report, we describe the rare combination of right radial and left ulnar deficiencies in 2 cases. Interestingly, 1 case had a history of 2 separate and apparently distinct episodes of bleeding during early gestation, whereas the other demonstrated associated hematoma formation early in development. These cases also demonstrate the susceptibility for ulnar defects on the left and radial defects on the right. The authors discuss the relationship of prenatal insults on limb development and the mechanisms underlying longitudinal deficiencies.
纵向缺陷的差异可能与早期肢体发育过程中损伤的时间和持续时间有关。在实验模型中，致畸性损伤在妊娠早期诱发尺骨缺陷比桡骨缺陷更早。在本报告中，我们描述了2例右桡骨和左尺骨缺陷的罕见组合。有趣的是，1例在妊娠早期有2次单独且明显不同的出血史，而另1例在发育早期出现相关血肿形成。这些病例还表明了左侧尺骨缺陷和右侧桡骨缺陷的易感性。作者讨论了产前损伤与肢体发育的关系以及纵向缺陷的潜在机制。
