Nair S, Carroll W D
Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3NE, UK.
Arch Dis Child. 2009 Sep;94(9):734-5. doi: 10.1136/adc.2008.156299.
We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid. There was widespread agreement that rifampicin was the likely cause of the thrombocytopenia. After discussion with the family we elected to continue treatment as we believed that the potential benefits of continuing treatment outweighed the risks of thrombocytopenia. Despite continued treatment the platelet count returned to normal after a few weeks. We found that thrombocytopaenia may be transient even when therapy is continued and would recommend a watchful waiting strategy to others faced with a similar clinical dilemma.
我们报告了一例13岁患结核病的女孩，在接受利福平及异烟肼治疗时出现持续性有症状性血小板减少症。大家普遍认为利福平可能是导致血小板减少症的原因。与患儿家属讨论后，我们决定继续治疗，因为我们认为继续治疗的潜在益处大于血小板减少症的风险。尽管持续治疗，但几周后血小板计数恢复正常。我们发现，即使继续治疗，血小板减少症也可能是短暂的，对于面临类似临床困境的其他人，我们建议采取密切观察等待的策略。
