Rajaleid Kristna, Hallqvist Johan, Koupil Ilona
Stockholm University/Karolinska Institute, Stockholm, Sweden.
Scand J Public Health. 2009 Sep;37(7):720-7. doi: 10.1177/1403494809344445. Epub 2009 Aug 21.
To study the association of size at birth and social circumstances at birth with 28 day case fatality of acute myocardial infarction (AMI).
Based on 1,776 first cases of AMI occurring in Uppsala Birth Cohort (men and women born 1915-1929) between 1964 and 2002. Data on circumstances at birth retrieved from archived obstetric records; data on social characteristics in adulthood, hospitalizations, and date of death obtained through linkage to Censuses, Hospital Discharge Register, and Cause of Death Register.
We found a U-shaped association between standardized birth weight and case fatality of AMI in men (p = 0.045 for age and period adjusted quadratic trend over quintiles of standardized birth weight) that was driven by cases of AMI occurring during the early years of follow-up. We found no association between standardized birth weight and case fatality of AMI in women. There was a statistically non-significant inverse association of AMI case fatality with social class at birth as well as with social class and household income in adulthood in the cohort. Marital status was a strong determinant of case fatality in men.
Standardized birth weight for gestational age was associated with case fatality of AMI in men. Social class at birth was weakly inversely associated with case fatality of AMI in the cohort.
研究出生时体重及出生时社会环境与急性心肌梗死（AMI）28天病死率之间的关联。
基于1964年至2002年间在乌普萨拉出生队列（1915年至1929年出生的男性和女性）中发生的1776例首次AMI病例。从存档的产科记录中获取出生时情况的数据；通过与人口普查、医院出院登记册和死亡原因登记册的关联获得成年期社会特征、住院情况和死亡日期的数据。
我们发现男性标准化出生体重与AMI病死率之间呈U形关联（按标准化出生体重五分位数调整年龄和时期的二次趋势，p = 0.045），这是由随访早期发生的AMI病例驱动的。我们未发现女性标准化出生体重与AMI病死率之间存在关联。在该队列中，AMI病死率与出生时社会阶层以及成年期社会阶层和家庭收入之间存在统计学上无显著意义的负相关。婚姻状况是男性病死率的一个重要决定因素。
孕周标准化出生体重与男性AMI病死率相关。出生时社会阶层与该队列中AMI病死率呈弱负相关。
