Circulatory Control Laboratory, Department of Physiology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Exp Physiol. 2010 Jan;95(1):41-50. doi: 10.1113/expphysiol.2008.046300. Epub 2009 Aug 21.
Since the first recording of sympathetic nerve activity (SNA) early last century, numerous methods for presentation of the resulting data have developed. In this paper, we discuss the common ways of describing SNA and their application to chronic recordings. Suggestions on assessing the quality of SNA are made, including the use of arterial pressure wave-triggered averages and nasopharyngeal stimuli. Calculation of the zero level of the SNA signal from recordings during ganglionic blockade, the average level between bursts and the minimum of arterial pressure wave-triggered averages are compared and shown to be equivalent. The use of normalization between zero and maximal SNA levels to allow comparison between groups is discussed. We recommend that measured microvolt levels of integrated SNA be presented (with the zero/noise level subtracted), along with burst amplitude and frequency information whenever possible. We propose that standardization of the quantifying/reporting of SNA will allow better comparison between disease models and between research groups and ultimately allow data to be more reflective of the human situation.
自上个世纪初首次记录交感神经活动 (SNA) 以来，已经开发出了许多呈现相关数据的方法。在本文中，我们讨论了描述 SNA 的常见方法及其在慢性记录中的应用。我们还提出了评估 SNA 质量的建议，包括使用动脉压力波触发平均和鼻咽刺激。比较了在神经节阻断期间的记录中计算 SNA 信号的零水平、爆发之间的平均水平和动脉压力波触发平均的最小值，结果表明它们是等效的。还讨论了使用 SNA 的零水平和最大水平之间的归一化来允许组间比较的问题。我们建议，尽可能地呈现测量的集成 SNA 的微伏水平（减去零/噪声水平），同时还呈现爆发幅度和频率信息。我们建议 SNA 的量化/报告标准化将允许更好地比较疾病模型和研究小组之间的数据，最终使数据更能反映人类的情况。
