与棉絮斑相关的视力丧失机制。
The mechanisms of vision loss associated with a cotton wool spot.
作者信息
Chui Toco Y P, Thibos Larry N, Bradley Arthur, Burns Stephen A
机构信息
School of Optometry, Indiana University, 800 E. Atwater Ave., Bloomington, IN 47405, USA.
出版信息
Vision Res. 2009 Nov;49(23):2826-34. doi: 10.1016/j.visres.2009.08.017. Epub 2009 Aug 22.
Abstract
We characterized the perceptual, functional, and structural abnormalities associated with retinal ischemia during a cotton wool spot episode and its sequelae. The border of the visually salient field anomaly mirrored the quantitatively measured relative scotoma. Results of resolution perimetry and high resolution imaging indicated that there was a substantial loss of retinal ganglion cells within the affected region. A disruption in retinal nerve fiber arrangement was found at the cotton wool spot and within the arcuate relative scotoma. The presence of the arcuate relative scotoma is consistent with the hypothesis of failed signal transmission along the axons that pass through the cotton wool spot. The different levels of loss associated with the arcuate and focal scotomas indicate different underlying pathologies.
摘要
我们对棉絮斑发作期间及后遗症期与视网膜缺血相关的感知、功能和结构异常进行了特征描述。视觉显著视野异常的边界与定量测量的相对暗点相符。分辨视野检查和高分辨率成像结果表明，受累区域内视网膜神经节细胞大量丢失。在棉絮斑处及弓形相对暗点内发现视网膜神经纤维排列紊乱。弓形相对暗点的存在与沿穿过棉絮斑的轴突信号传递失败的假说一致。与弓形和局灶性暗点相关的不同程度的损失表明存在不同的潜在病理情况。
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