Synthesis and biological evaluation of a novel cardiolipin affinity matrix.
作者信息
Johns Melloney K, Yin Meng-Xin, Conway Stuart J, Robinson Diane E J E, Wong Leon S-M, Bamert Rebecca, Wettenhall Richard E H, Holmes Andrew B
机构信息
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
出版信息
Org Biomol Chem. 2009 Sep 21;7(18):3691-7. doi: 10.1039/b909306k. Epub 2009 Jul 14.
DOI:10.1039/b909306k
PMID:19707673
Abstract
Cardiolipin (1) is a dimeric phospholipid found in the mitochondrial membranes of both plants and animals. In order to understand better its role, we report the preparation of an immobilised analogue (2) using phosphoramidite chemistry; the probe has been used successfully to bind a recombinant protein containing a cardiolipin-binding domain.
摘要
Zotero 插件