Burne R A, Ahn S-J, Wen Z T, Zeng L, Lemos J A, Abranches J, Nascimento M
Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida 32610-0424, USA.
Adv Dent Res. 2009;21(1):17-20. doi: 10.1177/0895937409335593. Epub 2009 Jul 31.
Bacteria adhere to a surface and, through cell division and coordinated expression of gene products, to develop into a structurally-complex population of adherent cells. This process, known as biofilm formation, requires that intrinsic and extrinsic signals are transduced into appropriate gene expression patterns as biofilms mature. Mutational analysis has begun to reveal the complexity of systems used by to ensure proper biofilm formation. These studies have revealed new and unique targets for the design of broadly-effective anti-caries strategies.
细菌附着于表面，并通过细胞分裂和基因产物的协调表达，发展成为结构复杂的附着细胞群体。这个过程，即生物膜形成，要求随着生物膜成熟，内在和外在信号被转导为适当的基因表达模式。突变分析已开始揭示细菌用于确保生物膜正确形成的系统的复杂性。这些研究揭示了用于设计广泛有效的防龋策略的新的独特靶点。
