Jonkhoff A R, Stricker B H
Academisch Ziekenhuis Vrije Universiteit, afd. Inwendige Geneeskun-de, Amsterdam.
Ned Tijdschr Geneeskd. 1990 Apr 28;134(17):863-5.
The case history is presented of a woman who developed an anaphylactic reaction after intake of floctafenine (Idalon). Thirty minutes after the ingestion of one tablet an urticarial rash appeared and shortly thereafter the patient became unconscious. Since 1976 12 similar cases have been reported to the Netherlands Centre for Monitoring of Adverse Reactions to Drugs. The chemical structure of floctafenine strongly resembles that of glafenine (a well-known cause of anaphylaxis) and the adverse reaction profile is probably similar. It is uncertain, however, whether anaphylactic reactions develop as frequently to floctafenine as to glafenine.
本文介绍了一名女性在服用氟考芬酯（Idalon）后发生过敏反应的病例。服用一片该药30分钟后出现荨麻疹皮疹，此后不久患者失去意识。自1976年以来，荷兰药物不良反应监测中心已收到12例类似病例报告。氟考芬酯的化学结构与格拉非宁（已知的过敏反应诱因）非常相似，不良反应情况可能也相似。然而，尚不确定氟考芬酯引起过敏反应的频率是否与格拉非宁一样高。
