Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
J Ovarian Res. 2009 Aug 27;2(1):11. doi: 10.1186/1757-2215-2-11.
MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by targeting messenger RNA (mRNA). Recently, it has been demonstrated that miRNA expression is altered in many human diseases including cancers, suggesting that miRNA may play a potential role in the pathogenesis of different diseases. It has also been reported that there is a unique expression pattern of miRNAs in the disease state differing from the normal state. In this review, we focus on the miRNA signatures in different human diseases including cancers. Such signatures may be used as diagnostic and prognostic markers.
微小 RNA（miRNAs）是一类小的非编码 RNA，通过靶向信使 RNA（mRNA）来控制基因表达。最近，已经证明 miRNA 的表达在许多人类疾病中发生改变，包括癌症，这表明 miRNA 可能在不同疾病的发病机制中发挥潜在作用。也有报道称，在疾病状态下 miRNA 的表达模式与正常状态不同。在这篇综述中，我们重点介绍了不同人类疾病（包括癌症）中的 miRNA 特征。这些特征可作为诊断和预后标志物。
